Three-dimensional reconstruction of the rat acinus

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Abstract
This study provides a quantitative description of the small airways and alveolar duct-alveolar architecture of the rat lung. To accomplish this, quantitative three-dimensional reconstructions were made of small airways, the alveolar duct system, and alveoli. The branching pattern of the small airways immediately proximal to the alveolar ducts varied significantly. For example, the number of bronchiole-alveolar duct junctions per parent bronchus (terminal bronchiole) ranged from two to six. The number of bronchiole-alveolar duct junctions per lung was 7,280 +/- 250 (mean +/- SE). The general shape of the ventilatory unit arising from each bronchiole-alveolar junction was that of a space-filling sphere with an outer diameter of 1,490 +/- 130 microns. The average distance from the bronchiole-alveolar duct junction to alveoli at the end of the alveolar sac termination was 1,290 +/- 100 microns. Numerous trifurcations were found in the branching pattern of the alveolar ducts. The branching of the alveolar ducts did not fit a regular dichotomous pattern. The volume of the terminal branches (alveolar sacs) accounted for 64 +/- 5% of the volume of the ventilatory unit. Both of these factors, the pattern of branching and the substantial volume distributed in the most peripheral branches, contribute to the uniform distribution of gas within the ventilatory unit and thus minimize potential diffusion limitations to gas exchange.

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