Evaluation of a new sustained release theophylline formulation by the measurements of salivary levels of the drug in humans.

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Abstract
Theophylline is widely used for the treatment of asthma and chronic obstructive lung diseases. Dry agar beads containing theophylline were prepared. The release rate of theophylline from the agar beads in vitro was smaller than the dissolution rate of the drug from pure drug powders. The salivary levels of the drug after oral administration of the agar beads to 3 healthy volunteers were determined by reversed-phase high pressure liquid chromatography. Results of pharmacokinetic analyses indicated sustained absorption of the drug after the administration of the agar beads.