Effect of methylglyoxal on tumour microtubular protein
- 1 January 1985
- journal article
- research article
- Published by Wiley in Cell Biochemistry and Function
- Vol. 3 (1) , 9-11
- https://doi.org/10.1002/cbf.290030104
Abstract
Methylglyoxal inhibits cell division, exerting an antiproliferative action on tumour cells. Supernatants from ascites hepatoma cell homogenate, previously incubated with the aldehyde, showed a decrease in colchicine binding activity dependent on methylglyoxal concentration. In contrast, in vivo treatment of tumour-bearing rats apparently did not cause a significant impairment of microtubular protein, suggesting that the aldehyde interaction with microtubules cannot be considered responsible for its carcinostatic action.Keywords
This publication has 6 references indexed in Scilit:
- Colchicine-binding properties of the hepatic tubulin/microtubule systemArchives of Biochemistry and Biophysics, 1980
- Biological Activity of Methylglyoxal and Related AldehydesPublished by Wiley ,1979
- The living state and cancer.Proceedings of the National Academy of Sciences, 1977
- Determination of protein: A modification of the lowry method that gives a linear photometric responseAnalytical Biochemistry, 1972
- Cancerostatic Action of MethylglyoxalScience, 1968
- Cell-Division and CancerScience, 1965