Rare renal neoplasms in Salmo gairdneri exposed to MNNG (N-methyl-N'-nitro-N-nitroso-guanidine)

1 January 1989

journal article
research article
Published by Inter-Research Science Center in Diseases of Aquatic Organisms

Vol. 6 (2) , 105-111
https://doi.org/10.3354/dao006105

Abstract

N-methyl-N''-nitro-N-nitrosoguanidine (MNNG) is a potent liver, stomach, kidney, and swimbladder carcinogen in rainbow trout Salmo gairdneri. Histopathological examination of tissues from trout exposed as fry to 50 ppm MNNG for 30 min revealed 2 types of neoplastic renal lesions not previously reported for this species. Renal cell carcinoma in the corpuscle of Stannius and renal cell, cystic, papillary adenoma of the mesonephric duct were diagnosed. Nephroblastoma and nephrocalcinotic lesions adjacent to the mesonephric duct adenoma suggested that occlusion of the duct could have been a contributing factor.

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