Accretion of Biopsy Specimens of Vaginal Adenosis From Patients Exposed in Utero to Diethylstilbestrol, When Transplanted to Athymic Nude Mice2
- 1 March 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 62 (3) , 521-523
- https://doi.org/10.1093/jnci/62.3.521
Abstract
Vaginal adenosis biopsy specimens from 10 patients exposed in utero to diethylstilbestrol were transplanted for 30 days into athymic (nude) mice. Almost all grafts were recovered, and they had morphologic features closely resembling those of the original biopsy specimens, i.e., cystic, complex, and simple occult glands covered mainly with an endocervical type of epithelium showing extensive squamous metaplasia. Autoradiographic analysis of these grafts after pulse administration of [3H]thymidine into the mice revealed extensive labeling of epithelial cells. These results imply that female athymic (nude) mice are compatible hosts for accretion of the human adenosis.Keywords
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