PATHOLOGICAL STUDY ON AMYLOIDOSIS – THE FINE STRUCTURE OF AMYLOID‐LADEN LIVER AS REVEALED BY FREEZE‐ETCHING

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Abstract
Amyloid in freeze-etched specimen of liver of mice receiving sodium caseinate s.c. was studied morphologically. The convex surface and cross surface of amyloid nodule were noted. The 3 dimensional structure of the amyloid fibrils which showed felt-like structure, globular profiles among amyloid fibrils and amyloid bundles were clearly visible. Amyloid bundles enveloped by the cytoplasmic membrane of the Kupffer cell projected from the deeply concave surface of the cytoplasmic membrane into the Disse''s space and showed the appearance of stone-column-like structure. The amyloid bundles projecting from the invaginated cytoplasmic membrane were closely in contact with the cytoplasmic membrane and deeply rooted in the cytoplasm of the Kupffer cell.