Thrombocytopenia Associated With PF3 Antiplatelet Activity Against the Sulfa Component of Trimethoprim-Sulfamethoxazole

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Abstract
A 3-yr-old white boy had symptomatic thrombocytopenia after receiving trimethoprim-sulfamethoxazole in recommended doses for 1 wk. Platelet count returned to normal soon after the medication was discontinued. In vitro admixing of donor platelets with a sample of the patient''s serum demonstrated antiplatelet activity with the sulfamethoxazole component, but not with the trimethoprim component of the drug.

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