Alkaloids of Cynoglossum latifolium R.Br. Latifoline and 7-Angelylretronecine

Abstract
The principal alkaloid of Cynoglossum latifolium R.Br. is latifoline, C20H27O7N, an ester of 7-angelylretronecine with the γ-lactone of 3,4-dihydroxypentane-2,3-dicarboxylic acid. 7-Angelylretronecine, itself, occurs as a minor constituent. Both alkaloids are subject to substantial decomposition during drying of the plant and 7-angelylretronecine may be formed by enzymatic attack on latifoline.

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