TEMPORAL AND SPATIAL DISTRIBUTION OF CHANGES DURING SPONTANEOUS SEIZURES IN MONKEY BRAIN

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Abstract
A scar produced in the cortex of a monkey by application of alumina cream was demonstrated to be chemically different from the rest of the cortex as shown by the random fluctuations of its noble metal potential but not by its pH. Occasionally- it exhibits electrical seizures of the general form seen in the cortex during grand mal seizures. These disturbances may spread through the felt-work of the cortex to contiguous areas or provoke similar disturbances in remote regions of the cortex and some deeper structures, but only in those to which the discharging region sends axons or collaterals. Changes in the pH and noble metal potential in a given region are the same and bear the same relation to the electrical discharge in it during the spontaneous seizure of the chronically convulsant cortex as during similar induced seizures. Like the scars from which such seizures arise in man, the lesion in the monkey''s cortex is characterized by a zone of increased vascularity, gliosis and pathological neurons.

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