Total Synthesis of a Structural Gene for the Human Peptide Hormone Angiotensin II
- 1 January 1975
- journal article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 356 (2) , 1585-1594
- https://doi.org/10.1515/bchm2.1975.356.2.1585
Abstract
Seven oligonucleotide chains containing between 6 and 11 nucleotide units were synthesized. The segments were phosphorylated by T4 polynucleotide 5'-hydroxyl-kinase and joined by T4 polynucleotide synthetase (ATP) to give the double-stranded DNA consisting of 33 base pairs. The DNA sequence was deduced from the known peptide sequence according to the genetic code.Keywords
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