Determination of a Common Clonal Origin of Gastric and Pulmonary Mucosa-Associated Lymphoid Tissue Lymphomas Presenting Five Years Apart.
- 1 January 1995
- journal article
- case report
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 34 (3) , 220-223
- https://doi.org/10.2169/internalmedicine.34.220
Abstract
Mucosa-associated lymphoid tissue (MALT) lymphoma is often mis-diagnosed as a benign tumor. Dissemination to other sites occurs in MALT lymphoma. We report a 60-year-old man with gastric and pulmonary tumors of MALT lymphoma which occurred 5 years apart. Initially, the gastric tumor had been diagnosed as reactive lymphoreticular hyperplasia. To determine whether the two tumors arose from the same malignant clone, we amplified and sequenced the complementarity-determining region 3 of the immunoglobulin heavy chain gene using the polymerase chain reaction (PCR). The sequences were identical except for 11-nucleotide difference, suggesting identical clonality.Keywords
This publication has 0 references indexed in Scilit: