Blood Volume and Aldosterone Secretion in Hypertension and Primary Aldosteronism.

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Abstract
Two cases of primary aldosteronism were demonstrated to have expanded extracellular fluid, total blood volume, and plasma volume, with restoration toward normal after removal of adrenocortical adenomas. Red cell volumes were normal in both. No increase in urinary aldosterone was observed in 5 patients with essential hypertension. Blood volume was normal or slightly decreased. Increased urinary aldosterone without hypervolemia was observed in 2 patients with malignant hypertension. Thus increased total blood volume in hypertensive patients, due solely to plasma volume and anemia (low hematocrit), should prove a useful addition to the diagnostic screen for primary aldosteronism.

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