Is the mesocortical dopaminergic system involved in Parkinson disease?
- 1 December 1980
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 30 (12) , 1326
- https://doi.org/10.1212/wnl.30.12.1326
Abstract
Tyrosine hydroxylase was used to identify catechol-aminergic neurons in the substantia nigra and ventral tegmental area of the human mesencephalon. High enzyme activity in the normal ventral tegmental area indicated the presence of numerous cathecholaminergic neurons, most likely dopamine cells. Tyrosine-hydroxylase activity was decreased in the ventral tegmental area of parkinsonian patients, implying a lesion of the mesocortical dopamine system in Parkinson disease.This publication has 9 references indexed in Scilit:
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