TOLERANCE AND IMMUNITY IN MICE INFECTED WITH HERPES-SIMPLEX VIRUS - STUDIES ON THE MECHANISM OF TOLERANCE TO DELAYED-TYPE HYPERSENSITIVITY

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 43  (2) , 363-369
Abstract
Tolerance to delayed-type hypersensitivity [DTH] is produced in mice following an i.v. injection of herpes simplex virus. This tolerance form is produced early on, following simultaneous injections of virus s.c. and i.v., and is long lasting (> 100 days). The early tolerance mechanism is resistant to high doses of cyclophosphamide and is not transferable by serum or spleen cells taken after 7 days. Spleen cells taken at 14 days onwards inhibit the induction of DTH when transferred to normal syngeneic recipients. These cells are T lymphocytes and are specific for the herpes type used in their induction.

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