Inhibition by Furosemide of Inflammatory Mediators from Lung Fragments
- 10 January 1991
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 324 (2) , 131
- https://doi.org/10.1056/nejm199101103240218
Abstract
Bianco and colleagues (Oct. 19, 1989, issue)1 reported that furosemide, when given as an aerosol, can prevent the early and late responses induced by allergen. The mechanism whereby furosemide protects the airways in response to allergen challenge could involve the release of inflammatory mediators from lung cells. We report the effect of furosemide on the in vitro release of sulfidopeptide leukotrienes and histamine from human lung tissue passively sensitized to Dermalophagoides pteronyssinus (the house-dust mite). This same allergen was used in 5 of the 11 subjects studied by Bianco et al.1Keywords
This publication has 3 references indexed in Scilit:
- Protective Effect of Inhaled Furosemide on Allergen-Induced Early and Late Asthmatic ReactionsNew England Journal of Medicine, 1989
- Effects of a 5-lipoxygenase inhibitor, REV-5901, on leukotriene and histamine release from human lung tissue in-vitroJournal of Pharmacy and Pharmacology, 1987
- Effect of fenoterol on immunological release of leukotrienes and histamine from human lung in vitro: Selective antagonism by β-adrenoceptor antagonistsEuropean Journal of Pharmacology, 1983