A NEW SYNTHETIC METHOD OF α,β-UNSATURATED KETONES VIA REGIOSELECTIVE REACTION OF ALLYL ANION FORMED FROM 2-MORPHOLINO-3-BUTENENITRILES (MASKED ACYL ANION EQUIVALENTS) WITH ALKYL HALIDES FOLLOWED BY HYDROLYSIS
- 5 August 1982
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 11 (8) , 1263-1266
- https://doi.org/10.1246/cl.1982.1263
Abstract
Treatment of 2-morpholino-3-butenenitriles and alkyl halides regioselectively afforded products alkylated on α-position to the nitrile group. The hydrolysis of the α-alkylation products gave the α,β-unsaturated ketones in good yields.This publication has 3 references indexed in Scilit:
- Stereoselective synthesis of .alpha.-sinensalJournal of the American Chemical Society, 1974
- The reaction of N-alkyl substituted α-aminoisobutyronitriles with carbonyl compoundsTetrahedron, 1968
- Ueber die Condensation von Aethylmethylketon mit BenzaldehydEuropean Journal of Inorganic Chemistry, 1902