Effects of ? 9-Tetrahydrocannabinol and pentobarbital on a cortical response evoked during conditioning
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 47 (1) , 119-122
- https://doi.org/10.1007/bf00428713
Abstract
A surface-negative wave, evoked by tone cues, appeared in monkey post-arcuate cortex as the monkey learned that the cue signaled the availability of reward. This evoked activity was depressed, concomitantly with changes in the animal's behavioral responding, by doses of Δ 9-tetrahydrocannabinol (Δ 9-Tetrahydrocannabinol-THC) as low as 0.032 mg/kg and of pentobarbital as low as 4 mg/kg. Pentobarbital tended to increase the latency of the evoked wave, an effect not seen with Δ 9-THC.Keywords
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