Thiobinupharidines Epimeric at C-1 and C-1′

Abstract
Thiobinupharidine epimers possessing axial methyl groups at C-1 and C-1′ have been isolated from extracts of Nupharluteum. 13C chemical shift data for the methyl and ring carbons demonstrate that both methyl groups are axial in 1-epi-1′-epi-thiobinupharidine and that one of two methyls is axial in 1-epi- and in 1′-epi-thiobinupharidine.

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