URINARY EXCRETION OF CATECHOL AMINES DURING INSULIN HYPOGLYCEMIA IN FIVE PATIENTS WITH ADDISON'S DISEASE AND IN ONE PATIENT AFTER BILATERAL ADRENALECTOMY

Publisher Website
Google Scholar
Abstract
Insulin hypoglycemia was induced by intravenous administration of either 0.05 or 0.1 I. U. insulin per kg body weight in order to obtain information about the functional state of the adrenal medulla. The patients received a maintenance dose of cortisone. The blood glucose concentrations were measured by the Hagedorn-Jensen method. The return of the blood sugar curve to fasting value was normal in 4 patients but retarded in 2. The typical response to hypoglycemia occurred in all patients. The absence of an increase in the urinary excretion of epinephrine found in this study constituted direct evidence that the adrenal medulla could not be stimulated to secrete. No changes in the excretion of catechol amines after histamine administration also supported this conclusion.

This publication has 2 references indexed in Scilit: