Effects of Iridoids on Sex- and Learning-Behaviours in Chronic Stressed Mice

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Abstract
Effects of iridoid glycosides on sex- and learning-behaviours induced by chronic "handing stress" in mice, were studied. Drugs at a dose of 50 mg/kg were given orally every day after the exposure to stress. Geniposide and geniposidic acid showed a protective effect against decrease in sex behaviours, acceleration of extinction of memory, increase in failure of retrieval of memory, decrease of rectal temperature and enlargement of adrenal gland induced by the exposure to stress. Genipin showed a protective effect against decrease in licking, acceleration of extinction of memory, increase in failure of retrieval of memory and enlargement of adrenal gland, but promoted decrease in rectal temperature. Monotropein and gardenoside showed a weak protective effect against decrease in sex behaviours and acceleration of extinction of memory. Catalpol, aucubin and mussaenoside showed a weak protective effect against acceleration of extinction of memory, and mussaenoside showed an additional protective effect against increase in failure of retrieval of memory and decrease in rectal temperature.

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