EVALUATION OF MECHANICAL VENTILATION IN NEWBORN INFANTS: II. Pulmonary and neuro‐developmental sequelae in relation to original diagnosis

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Abstract
Incidence of bronchopulmonary dysplasia (BPD) and neuro-developmental sequelae in 135 [human] infants surviving intermittent positive pressure ventilation (IPPV) in the newborn period were studied in relation to primary disorders requiring IPPV. Rate of BPD increased over the 6 yr study period in hyaline membrane disease survivors from 14-28%, but decreased in infants with apnea repetens from 38-13%. Immaturity seemed to be one important factor for development of BPD. The incidence of neuro-developmental sequelae in IPPV treated infants fell from 22-13%. In infants with birth wt below 1501 g the rate of neurological handicaps was 11%.