EVIDENCE OF A THROMBOXANE A2-CA-2+ COMPLEX - A CONFORMATIONAL APPROACH
- 1 January 1984
- journal article
- research article
- Vol. 46 (2) , 175-185
Abstract
Thromboxane A2 has been proposed as an ionophore capable to transport Ca from the platelet dense tubular system to the cytoplasm to activate the contractile proteins. However, the half-life (30 s) of this compound limits considerably the experimental approach. The conformational analysis is proposed here as a possible way to identify such transient conformations. There is evidence of the existence of 2 Ca2+-thromboxane A2 isomeric complexes: one structure responsible for the complexation-decomplexation process at the interface and one lipophilic structure able to cross the lipid membrane.This publication has 3 references indexed in Scilit:
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- Conformational analysis of the calcium--A23187 complex at a lipid--water interface.Proceedings of the National Academy of Sciences, 1982
- Analytical potentials from "ab initio" computations for the interaction between biomolecules. 2. Water with the four bases of DNAJournal of the American Chemical Society, 1977