APOMORPHINE HYPOTHERMIA - INTERACTION WITH SEROTONERGIC AGENTS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 32  (1) , 15-20
Abstract
Apomorphine (APO, 0.25-16 mg/kg) induced a dose-dependent hypothermia in mice. Haloperidol, a dopamine antagonist, antagonized APO hypothermia due to lower doses; clozapine and phenoxybenzamine failed to modify APO hypothermia. l-Propranolol and cyproheptadine, which modify serotonergic responses, failed to modify APO hypothermia; fluoxetine, which selectively inhibits serotonin uptake, reversed APO-induced hypothermia due to higher doses but not that induced by low dose of APO. The behavioral stereotypy was not modified by fluoxetine pretreatment. APO hypothermia due to lower and higher doses is mediated by different receptors, and the latter action involves the interaction of more than 1 type of receptor.