Diastereoselective Synthesis of Cyclopentanoids with Hydantoin and Isoxazoline Substituents
- 1 January 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 63 (1) , 113-117
- https://doi.org/10.1021/jo9714831
Abstract
Exploiting 1,3-dipolar cycloaddition and urea → hydantoin cyclization transformations, novel spiro[cyclopenta[d]isoxazole-4‘,5-imidazolindine] heterocycles of generalized structure I have been prepared. The 1-amino-3-cyclopentenecarboxylate precursor II was prepared from a suitably activated/protected derivative of glycine and the bis-alkylating agent cis-1,4-dichloro-2-butene.Keywords
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