Dementia and Low Testosterone and Bioavailable Testosterone Levels in Men
- 1 July 2006
- journal article
- Published by Wolters Kluwer Health in Alzheimer Disease & Associated Disorders
- Vol. 20 (3) , 138-140
- https://doi.org/10.1097/00002093-200607000-00003
Abstract
This study examines associations of serum total and bioavailable testosterone (T) with dementia in a community-based cohort of men. Study subjects (n=128; ages 65 y and older at baseline) were recruited in 1990 and followed through 2006. Dementia was assessed from the subject medical records on the basis of the criteria from the Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Serum from a blood draw performed in 1994 was assayed for total and bioavailable T. Twenty-one men developed dementia over 1186 person-years of follow-up. The cumulative incidence of dementia was 14.7% in men with total TKeywords
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