Single‐phase chromatography: Solute retardation by ultrafiltration and electrophoresis

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Abstract
It is suggested that chromatographic separations can be performed very effectively in the absence of a stationary sorbent phase by using small diameter tubes or tube bundles for the column and segregating the solutes radially into the slower moving fluid near the tube walls. Separation is achieved by differential solute retardation whenever the degree of segregation is different for the various solute species present.An approximate analysis and preliminary experimental studies demonstrate the feasibility of using ultrafiltration through the tube wall to achieve solute separation. Preliminary estimates based on our ultrafiltration analysis also show that segregation by electromigration is very promising for electrically charged solutes.

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