Reaction of the Diaphragm to Denervation

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Abstract
Left hemidiaphragm denervation in the rat is followed in 7 days by a 22.9% increase in left hemidiaphragm wet weight, a 2.9% increase in water, no change in dry weight, and a marked loss in creatine. Wet weight and water increase subsided by the 21st day; wet and dry weight and creatine decreased through the 70th day. Opposite intact right hemidiaphragm was unaffected by paralysis of the left, through the 28th day, then both lost wet and dry weight from 42nd through 70th days. Right hemidiaphragm denervation resulted in no significant change in wet or dry weight or water up to the 28th day, then wet and dry weights and creatine progressively declined. Opposite left non-denervated hemidiaphragms were unchanged. After simultaneous bilateral hemidiaphragm denervation, changes occurring in left and right hemidiaphragms were the same as when hemidiaphragms were denervated separately. The transient increase in wet weight of left hemidiaphragms 1 week after denervation can be accounted for by an increase in tissue water. Since there was no dry weight or creatine increase paralleling wet weight increase, a true hypertrophy cannot have occurred. Difference in response of left and right hemidiaphragms to denervation may be explained on the basis of differences in vascular pattern of the 2 halves.

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