Dopamine D2 receptor gene Ser311Cys variant and schizophrenia: association study and meta‐analysis

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Abstract
An association has been reported between a dopamine D2 receptor gene (DRD2) Ser311Cys variant and schizophrenia. In a replication attempt, Swedish patients with schizophrenia (n = 173) and control subjects (n = 236) were assessed for the DRD2 Ser311Cys variant. Schizophrenic patients displayed higher Cys311 allele frequencies than control subjects (4.0 vs. 0.8%, χ2 = 9.49, df = 1, P = 0.002; odds ratio (OR) 4.93, 95% confidence interval (95% CI) 1.61–15.12). The association was detected only in men. The results were supported by a meta‐analysis of all published case–control studies comprising a total of 9,152 subjects (χ2 = 11.37, df = 1, P < 0.001; OR 1.43, 95% CI 1.16–1.78). The present results support the involvement of the DRD2 gene in the pathogenesis of schizophrenia.
Funding Information
  • Swedish Medical Research Council (3560)
  • National Institute of Mental Health (NIMH) (44814)
  • Wallenberg Foundation
  • HUBIN project