Latency of a thymidine kinase-negative pseudorabies vaccine virus detected by the polymerase chain reaction
- 1 September 1992
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 122 (3-4) , 341-348
- https://doi.org/10.1007/bf01317195
Abstract
Summary Latent viral DNA was detected by the polymerase chain reaction in trigeminal ganglia of all of 10 pigs that were necropsied 81 or more days after they had been infected intranasally with a thymidine kinase-negative (TK−) vaccine strain of pseudorabies virus (PRV). Failure to reactivate virus from any of the same pigs by earlier treatment with dexamethasone suggested that even though latency can be established with TK− PRV, subsequent reactivation may be a relatively rare event.Keywords
This publication has 32 references indexed in Scilit:
- Anamnestic Immune Response of Pigs to Pseudorabies Virus: Latent Virus Reactivation versus Direct Oronasal and Parenteral Exposure to VirusJournal of Veterinary Diagnostic Investigation, 1991
- Virus reactivation in pigs latently infected with a thymidine kinase negative vaccine strain of pseudorabies virusArchiv für die gesamte Virusforschung, 1991
- Detection of latent thymidine kinase-deficient herpes simplex virus in trigeminal ganglia of mice using the polymerase chain reactionArchiv für die gesamte Virusforschung, 1990
- Sequential Changes in the Humoral Immune Response of Pigs to Pseudorabies Virus after Vaccination, Exposure to Virulent Virus, and Reactivation of Latent VirusJournal of Veterinary Diagnostic Investigation, 1990
- Detection of pseudorabies virus DNA sequences by the polymerase chain reactionArchiv für die gesamte Virusforschung, 1989
- The Role of Herpes Simplex Virus Type 1 Thymidine Kinase in PathogenesisJournal of General Virology, 1989
- Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA PolymeraseScience, 1988
- Herpesvirus (pseudorabies virus) latency in swine: Occurrence and physical state of viral DNA in neural tissuesVirology, 1986
- Occurrence and reactivation of latent Aujeszky's disease virus following challenge in previously vaccinated pigsArchiv für die gesamte Virusforschung, 1983
- Differentiation of pseudorabies (Aujeszky's disease) virus strains by restriction endonuclease analysisArchiv für die gesamte Virusforschung, 1982