Suppression of transmitter release at the neuromuscular junction
- 4 April 1977
- journal article
- Published by The Royal Society in Proceedings of the Royal Society of London. B. Biological Sciences
- Vol. 196 (1125) , 465-469
- https://doi.org/10.1098/rspb.1977.0051
Abstract
Tetrodotoxin and tetraethylammonium were used on frog and rat end-plates, to inhibit voltage-activated sodium and potassium currents. Under these conditions, large endplate potentials can be evoked by applying super-threshold depolarizing current pulses (of 50-100 ms duration) to the motor nerve endings. When the current intensity is increased several-fold above threshold, the response is suppressed during the current flow, and delayed until the pulse is terminated. This phenomenon is similar to and complements earlier observations on the squid giant synapse.Keywords
This publication has 3 references indexed in Scilit:
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- The release of acetylcholine from nerve endings by graded electric pulsesProceedings of the Royal Society of London. B. Biological Sciences, 1967
- Input–Output Relation of a Single SynapseNature, 1966