Activity of 3-oxo acid CoA-transferase, d-3-hydroxybutyrate dehydrogenase, hexokinase and carnitine palmitoyltransferase in the stomach and small and large intestine of the rat

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Abstract
The activities of 3-oxo acid CoA-transferase, D-3-hydroxybutyrate dehydrogenase, hexokinase and carnitine palmitoyltransferase were measured in the gastrointestinal tract. The activity of 3-oxo acid CoA-transferase in the glandular mucosa of the stomach was as high as that in heart and kidney and was 2-4 times greater than that in other regions of the gastrointestinal tract. Metabolism of acetoacetate might support acid secretion on refeeding after a period without food. All regions of the gastrointestinal tract have the capacity to use ketone bodies and it is likely that muscle and mucosa will contribute to their utilization. The activity of hexokinase was twice the rate of glucose utilization by the jejunum under anaerobic conditions. The maximal rate of glucose metabolism in the jejunum may not be substantially different from that in other regions of the gastrointestinal tract. Starvation decreased the capacity for metabolism of glucose in several regions of the intestine. The activities of carnitine palmitoyltransferase in the stomach, jejunum and colon were similar and .apprx. 1/3 of that in the liver. Activity in the jejunum was much higher than the apparent rate of oxidation of exogenous fatty acid. The results do not suggest any large variation between tissues of the gastrointestinal tract in metabolism of glucose or fatty acids, whereas metabolism of ketone bodies may be more prominent in the stomach.