Genetic Control of Resistance to Subgroup A and Subgroup C Tumour Viruses in Rhode Island Red Fowl: Evidence for Linkage between the Tumour Virus a (tva) and Tumour Virus c (tvc) Loci

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Abstract
The Rhode Island Red (RIR) strain of fowl maintained at Houghton Poultry Research Station [United Kingdom] was used to investigate the genetic control of cellular response to infection with subgroup A and C oncornaviruses. Family matings within the RIR strain and test-crosses between the RIR parents and White Leghorn (WL) parents of known ararcrcr genotype were set up to ascertain linkage between the tumor virus a (tva) and tumor virus c (tvc) loci. In the RIR strain the tva and tvc loci control the cellular response to viruses of subgroups A and C, respectively, as reported for other fowl breeds (WL and New Hampshire). As in WL fowl, the 2 loci are linked. The linkage value of 0.22 in males agreed well with that reproted for WL males, indicating that the 2 loci are located in the same sites in homologous chromosomes in the 2 breeds. In the RIR strain, no sex difference in crossing over between the 2 linked loci was found; in WL fowl the absence of crossing over between the 2 loci was observed in the heterogametic female sex.