Elevated levels of a somatomedin-binding protein PP12 in patients with ovarian cancer
- 15 November 1986
- Vol. 58 (10) , 2294-2297
- https://doi.org/10.1002/1097-0142(19861115)58:10<2294::aid-cncr2820581023>3.0.co;2-q
Abstract
The circulating levels of placental protein 12 (PP12), a somatomedin-binding protein, were measured by radioimmunoassay in 37 postmenopausal women with ovarian tumors. Elevated levels (above 47 μg/1) were observed in 16 of 25 patients (64%) with malignant and 2 of 12 patients (17%) with benign tumors. Elevated levels were more frequent and higher in patients with advanced disease. Within 1 week of surgery, the levels fell in 13 of 17 cases (77%). In addition to clinical interest, these results contribute to our knowledge of carrier proteins of growth factors in patients bearing malignant ovarian neoplasms.This publication has 13 references indexed in Scilit:
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