Effects of Protein Depletion and Repletion on Serum Electrophoretic Patterns of Adult Rats.

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Abstract
The distribution of serum proteins was determined by filter paper electrophoresis in groups of adult rats during protein depletion and repletion. The animals were depleted by feeding a protein-free diet and were sacrificed after weight losses of 10, 25, 33, and 40% of their original weight. Other groups were sacrificed after regaining 35, 70, and 100% of their lost weight following 25% repletion. In the early stages of protein depletion and repletion, body weight changes were paralleled to a considerable extent by similar alterations in serum protein levels. Such correlation was not apparent during later stages. The albumin and a1-globulin fractions were most sensitive to nutritional influences. The gamma-globulin fraction deviated from the general pattern of response.

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