IMMUNE DYSREGULATION IN HUMAN TUBERCULOSIS

  • 1 August 1986
    • journal article
    • research article
    • Vol. 108  (2) , 142-149
Abstract
Hyporesponsiveness to mycobacterial antigens occurs in some patients with tuberculosis. Active immunosuppression by monocytes, T-lymphocytes, and serum is evident and may be a critical factor in anergy. The molecular basis for depressed responsiveness to tuberculin antigens is uncertain, but may involve aberrant surface expression of the HLA-DR gene product on adherent mononuclear cells and abnormalities in immune induction and the cytokine cascade.

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