NEW SESQUITERPENE LACTONES FROM EUPATORIUM SACHALINENSE (FR. SCHMIDT) MAKINO

Abstract
Three new germacranolide sesquiterpene lactones, peroxysachalinin, sachalinin, and sachalin, were isolated from Eupatorium sachalinense (Fr. Schmidt) Makino and their structures were described. An allyl hydroperoxy sesquiterpene lactone, peroxysachalinin, was characterized by spectral and chemical methods and prepared by photosensitized oxygenation of eupatoriopicrin which was a main component of this plant. Peroxysachalinin was converted to sachalinin with triphenylphosphine, whereas sachalinin was converted to sachalin.

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