Pyochelin: novel structure of an iron-chelating growth promoter for Pseudomonas aeruginosa.
- 1 July 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (7) , 4256-4260
- https://doi.org/10.1073/pnas.78.7.4256
Abstract
Pyochelin, an endogenous growth promoter that solubilizes ferric iron, was isolated from P. aeruginosa, including clinical strains. The structure of pyochelin was 2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid and is of a different type from those previously assigned to siderophores (siderochromes) from bacteria. The assignment rests on 1H and 13C NMR data, high-resolution (including field desorption) mass spectrometry, and spectroscopic properties of synthetic model compounds. Pyochelin is presumed to be biosynthesized from salicyclic acid and 2 mol of cysteine.This publication has 10 references indexed in Scilit:
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