Identifiability Analysis of an In Vivo Receptor-Binding Radiopharmacokinetic System
- 1 May 1985
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Biomedical Engineering
- Vol. BME-32 (5) , 312-322
- https://doi.org/10.1109/tbme.1985.325544
Abstract
A five-state, nonlinear model describing the pharmacokinetics of a receptor-binding radiopharmaceutical is presented. Local parameter identifiability analysis was performed preexperimentally to investigate the chemical and observational conditions required for adequate estimates of hepatic blood flow, receptor-ligand affinity, and receptor population. The ability to estimate the above parameters from externally observed kinetic data depended upon receptor-ligand affinity, the molar dose of the radiopharmaceutical, the number and coupling of the observers, and independent knowledge of the coupling coefficients or ligand-receptor affinity.Keywords
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