Inquiry into the Limits of Biological Effects of Chemical Compounds in Tissue Culture, I
Open Access
- 1 October 1975
- journal article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung C
- Vol. 30 (9-10) , 643-649
- https://doi.org/10.1515/znc-1975-9-1015
Abstract
Experiments were designed to investigate the low-dose side of the so-called dose-effect relation of mercuric chloride on the proliferation of a murine lymphoblastic cell strain (MB VIa). Three concentration ranges, from 0.9 × 10-5 м to 0.9 × 10-18 м, from 0.9 × 10-12 м to 0.9 × 10-25 м , and from 0.9 × 10-15 м to 0.9 x 10-21 м, in which the concentration decreased stepwise by a factor 10, were studied in 61, 74 and 58 experimental repetitions, respectively. In the first range, the concentrations 0.9 × 10-5 M and 0.9 x 10-6 м HgCl2 proved to be definitely toxic as was expected. However, also 0.9 × 10-16 м and 0.9 × 10-17 м appeared to be growth-inhibiting, the latter results being confirmed in the second and the third concentration ranges. These differences in cell growth were statistically significant.Keywords
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