Volume flow across choroidal ependyma of the rabbit

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Abstract
Venous blood obtained by micropuncture from the principal draining vein of the choroid plexus was compared with mixed arterial blood and with artificial bathing solutions. During secretion into a bath approximately isoosmolal with plasma there was no significant difference between thawing points of mixed arterial and choroidal venous plasma, nor did a difference develop when the transependymal volume flow was speeded by isoosmolal replacement of electrolytes by nonelectrolytes in the bath. A net volume flow continued into a quite hypotonic bath (1/2 Tyrode). A coefficient of osmotic flow of .28 x 10-11 cm3/dyne sec was estimated when the added solute was sucrose. Solute and volume flows were uncoupled under the influence of acetazolamide, a hypertonic secretion at a reduced rate being the invariable result.

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