Association between smaller left posterior superior temporal gyrus volume on magnetic resonance imaging and smaller left temporal P300 amplitude in first-episode schizophrenia.

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Abstract
THE MOST replicated electrophysiologic abnormality in schizophrenia is amplitude reduction of the auditory P300.1-3 This event-related potential (ERP) is elicited when subjects detect rare target tones among differently pitched tones. Abnormalities in P300 may reflect deficits in cognitive updating, information processing, and selective attention.4-6 The P300 reduction in schizophrenia cannot be attributed to latency variability on individual trials or to absence of P300 on a subset of target trials,7-9 and persists even when clinical improvement is observed.8,10,11