IDENTIFICATION OF 3-O-METHYL-ALPHA-METHYLDOPAMINE AS A URINARY METABOLITE OF 3,4-METHYLENEDIOXYAMPHETAMINE IN DOG AND MONKEY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 5  (2) , 143-148
Abstract
3-O-Methyl-.alpha.-methyldopamine was separated by GLC as a metabolite of MDA [3,4-methylene dioxyamphetamine] in the urine of dog and monkey [Macaca mulatta]. The metabolite was identified as its mono- and di-trifluoroacetyl derivatives by comparison of their GLC and GLC-mass spectral properties with those of synthetic compounds. The amount of metabolite increased on hydrolyzing the urine from dosed dogs and monkeys with a preparation containing .beta.-glucuronidase and sulfatase [MDA is a frequently abused drug.].

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