First Linezolid-Resistant Clinical Isolates of Mycobacterium tuberculosis
- 1 April 2007
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 51 (4) , 1534-1536
- https://doi.org/10.1128/aac.01113-06
Abstract
Linezolid resistance was found in 4 (1.9%) of 210 multidrug-resistant Mycobacterium tuberculosis strains. The MICs of linezolid were 4 μg/ml (one strain) and 8 μg/ml (three strains). Since no mutations were detected in potential target genes, the mechanism of resistance remains unclear.Keywords
This publication has 12 references indexed in Scilit:
- Multicenter Laboratory Validation of the BACTEC MGIT 960 Technique for Testing Susceptibilities of Mycobacterium tuberculosis to Classical Second-Line Drugs and Newer AntimicrobialsJournal of Clinical Microbiology, 2006
- Rapid Detection of Mycobacterium tuberculosis Beijing Genotype Strains by Real-Time PCRJournal of Clinical Microbiology, 2006
- mmpL7 Gene of Mycobacterium tuberculosis Is Responsible for Isoniazid Efflux in Mycobacterium smegmatisAntimicrobial Agents and Chemotherapy, 2005
- Novel Mechanism of Resistance to Oxazolidinones, Macrolides, and Chloramphenicol in Ribosomal Protein L4 of the PneumococcusAntimicrobial Agents and Chemotherapy, 2005
- Oxazolidinones: activity, mode of action, and mechanism of resistanceInternational Journal of Antimicrobial Agents, 2004
- Ribosomal and non‐ribosomal resistance to oxazolidinones: species‐specific idiosyncrasy of ribosomal alterationsMolecular Microbiology, 2002
- Oxazolidinones: a new class of antibacterialsCurrent Opinion in Pharmacology, 2001
- Pharmacokinetics and Tissue Penetration of Linezolid following Multiple Oral DosesAntimicrobial Agents and Chemotherapy, 2001
- Mechanism of action of the oxazolidinone antibacterial agentsExpert Opinion on Investigational Drugs, 1999
- The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycinAntimicrobial Agents and Chemotherapy, 1997