Mixed connective tissue disease

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Abstract
Three patients with mixed connective tissue disease (MCTD) had clinical features that included a high incidence of Raynaud''s phenomenon, arthritis, myositis and swollen hands. Diagnostic laboratory test results demonstrated the presence of high titers of antibody to extractable nuclear antigen. These antibody titers are notably reduced or abolished in patients with MCTD when the tanned red blood cells that are used in the test are pretreated with RNase. Speckled antinuclear antibodies were present in all patients. Patients with MCTD have a low incidence of renal disease, are responsive to treatment with prednisone, and have a good prognosis.

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