Elevated Concentration of Adenosine 3′:5′-Cyclic Monophosphate in Intestinal Mucosa after Treatment with Cholera Toxin
- 1 October 1970
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 67 (2) , 851-856
- https://doi.org/10.1073/pnas.67.2.851
Abstract
A heat-labile factor in cell-free filtrate of a Vibrio cholerae culture induces a marked rise in the wet-weight concentration of adenosine 3':5'-cyclic monophosphate (cyclic AMP) in the intestinal mucosa of the dog. The increase becomes appreciable 1-1.5 hr after intraluminal administration of the filtrate, about the same time as the onset of intestinal secretion in response to a heat-labile enterotoxin in the filtrate. These results are consistent with the hypothesis that cyclic AMP may be an intermediary in the intestinal secretory response to cholera toxin.Keywords
This publication has 19 references indexed in Scilit:
- Stimulation of Glycerol Production in Fat Cells by Cholera ToxinNature, 1970
- Digestion: Intestinal SecretionAnnual Review of Physiology, 1970
- The role of cyclic adenosine-3',5'-monophosphate (AMP) in gastrointestinal secretion.Gut, 1969
- Cholera ToxinsAnnual Review of Microbiology, 1968
- Cyclic AMPAnnual Review of Biochemistry, 1968
- Site and characteristics of electrolyte loss and effect of intraluminal glucose in experimental canine choleraJournal of Clinical Investigation, 1968
- Effects of Vasopressin, Theophylline and Cyclic Adenosine Monophosphate on Short-circuit Current across Isolated Rabbit Ileal MucosaNature, 1968
- A Permeability Factor (Toxin) Found in Cholera Stools and Culture Filtrates and its Neutralization by Convalescent Cholera SeraNature, 1965
- Isolation of adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate from rat urineBiochemical and Biophysical Research Communications, 1963
- Molecular Properties and Transformations of Glycogen Phosphorylase in Animal TissuesPublished by Wiley ,1962