Leukotrienes in Asthma and Allergic Rhinitis

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Abstract
The term "slow-reacting substance of anaphylaxis" was coined originally to describe tissue effluent released during an antigen–antibody reaction that triggered a prolonged contraction of smooth muscle.1 , 2 Initial descriptions of this biologic activity in fluids primarily derived from lung tissue led to the characterization of a new family of molecules called leukotrienes.3 Subsequent studies by a number of investigators4 defined the enzymatic modifications of arachidonic acid derived from cell membranes that were required to generate leukotriene B4 and the cysteinyl leukotrienes (leukotrienes C4, D4, and E4). The cysteinyl leukotrienes are responsible for the biologic . . .