ALUMINUM IN THE JOINT TISSUES OF CHRONIC-RENAL-FAILURE PATIENTS TREATED WITH REGULAR HEMODIALYSIS AND ALUMINUM COMPOUNDS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 11  (1) , 66-70
Abstract
The concentrations of Al in the articular tissues of 5 hemodialyzed patients treated with Al compounds. Al crosses the synovial barrier, is found in synovial fluid (SF) and accumulates in the joint structures (synovial membrane and joint cartilage). The concentrations found in synovial tissue were 2.7-10 times control values, in SF 2.5-8 times the control concentrations and in cartilage 2.6 times the control concentrations. Transmission electron microscopy showed localization of Al in the lysosomal structures and wavelength dispersive microprobe analysis showed Al in cellular components associated with phosphate. The possible toxicity of Al to joints merits further investigations.

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