The Multiple Roles of sGP in Ebola Pathogenesis
- 1 February 2015
- journal article
- review article
- Published by Mary Ann Liebert Inc in Viral Immunology
- Vol. 28 (1) , 3-9
- https://doi.org/10.1089/vim.2014.0068
Abstract
Ebola causes severe hemorrhagic fever in humans and nonhuman primates, and there are currently no approved therapeutic countermeasures. The virulence of Ebola virus (EBOV) may be partially attributed to the secreted glycoprotein (sGP), which is the main product transcribed from its GP gene. sGP is secreted from infected cells and can be readily detected in the serum of EBOV-infected hosts. This review summarizes the multiple roles that sGP may play during infection and highlights the implications for the future design of vaccines and treatments.Keywords
This publication has 66 references indexed in Scilit:
- Ebola Virus Does Not Block Apoptotic Signaling PathwaysJournal of Virology, 2013
- Ebola virus entry requires the host-programmed recognition of an intracellular receptorThe EMBO Journal, 2012
- Ebola haemorrhagic fever outbreak in Masindi District, Uganda: outbreak description and lessons learnedBMC Infectious Diseases, 2011
- sGP Serves as a Structural Protein in Ebola Virus InfectionThe Journal of Infectious Diseases, 2011
- Ebolavirus Δ-Peptide Immunoadhesins Inhibit Marburgvirus and Ebolavirus Cell EntryJournal of Virology, 2011
- A New Ebola Virus Nonstructural Glycoprotein Expressed through RNA EditingJournal of Virology, 2011
- Ebola haemorrhagic feverPublished by Elsevier ,2010
- Nipah Virus Edits Its P Gene at High Frequency To Express the V and W ProteinsJournal of Virology, 2009
- Structure of the Ebola virus glycoprotein bound to an antibody from a human survivorNature, 2008
- Influences of Glycosylation on Antigenicity, Immunogenicity, and Protective Efficacy of Ebola Virus GP DNA VaccinesJournal of Virology, 2007