Pseudohypertension in Sinoaortic-Denervated Rats

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Abstract
1. Mean arterial pressure was determined continuously over a 24-h period by computerized data collection in eight control and nine sinoaortic-denervated rats housed in standard-sized metabolic cages. In addition, direct and indirect pressure measurements were made while the rats were resting in a Lucite restrainer. 2. Pressure measurements made during restraint indicated that the baroreceptor-denervated rats were hypertensive: mean aortic pressure averaged 145 ± 3.4 mmHg (mean ± sem) in denervated rats vs 119 ± 2.8 mmHg in control rats (PP<0.001). 3. In contrast, continuous pressure monitoring showed the sinoaortic-denervated rats were normotensive (mean arterial pressure averaged 119 ± 4.7 mmHg vs 119 ± 3.1 mmHg in control rats). 4. Apparently arterial pressure is elevated during restraint in sinoaortic-denervated rats and pressure measurements made under these conditions give a false indication of hypertension.

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