5‐Methylnaioxone and 5‐Methylnaltrexone: Synthesis and Pharmacological Evaluation
- 25 October 1990
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 73 (7) , 1986-1990
- https://doi.org/10.1002/hlca.19900730722
Abstract
Starting from 5‐methyl‐oxycodone (6), 5‐methylnaloxone (4), and 5‐methylnaltrexone (5) have been prepared in several steps. Both 4 and 5 behaved as partial agonists in the AcOH writhing agonism and antagonism test in mice.This publication has 19 references indexed in Scilit:
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